Does 2Do support syncing with Exchange?

Mac app first

Some sync capabilities mentioned here, such as Merge sync and Todoist, are currently available in 2Do for Mac and are coming to the iOS app in an upcoming update.

No. 2Do currently supports syncing with Dropbox, WebDAV, Apple Reminders, Todoist, Toodledo, and CalDAV servers (such as iCloud CalDAV, Fruux, Yahoo!, Nextcloud, SabreDAV, and so on). Exchange is not one of them. See Which sync method should I use? or the Sync overview (Mac) for the full list.

Adding an Exchange account to your Mac or iOS Calendar app can make its events visible in 2Do's calendar views — the Calendar Events view on iPhone and iPad, or the Calendar Events day bar above the Today list on Mac — but it does not enable Exchange task synchronization in 2Do.